Aminoglycoside-modifying enzymes in high-level streptomycin and gentamicin resistant Enterococcus spp strains in Spain.

  1. Del Campo, R. 2
  2. Tenorio, C. 1
  3. Rubio, C. 2
  4. Castillo, J. 2
  5. Torres, C. 1
  6. Gómez-Lus, R. 2
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Universidad de Zaragoza
    info

    Universidad de Zaragoza

    Zaragoza, España

    ROR https://ror.org/012a91z28

Revista:
International Journal of Antimicrobial Agents

ISSN: 0924-8579

Año de publicación: 2000

Volumen: 15

Número: 3

Páginas: 221-226

Tipo: Artículo

DOI: 10.1016/S0924-8579(00)00169-2 PMID: 10926445 SCOPUS: 2-s2.0-0033837396 WoS: WOS:000088206800009 GOOGLE SCHOLAR

Otras publicaciones en: International Journal of Antimicrobial Agents

Archivo institucional: lock_openAcceso abierto editor
bar_chart Ver indicadores

Indicadores

Citas recibidas

  • Citas en Scopus: 57 (09-09-2023)
  • Citas en Web of Science: 53 (07-09-2023)
  • Citas en Dimensions: 46 (30-03-2023)

JCR (Journal Impact Factor)

  • Año 2000
  • Factor de impacto de la revista: 1.141
  • Factor de impacto sin autocitas: 1.047
  • Article influence score: 0.0
  • Cuartil mayor: Q3
  • Área: MICROBIOLOGY Cuartil: Q3 Posición en el área: 50/83 (Edicion: SCIE)
  • Área: PHARMACOLOGY & PHARMACY Cuartil: Q3 Posición en el área: 105/181 (Edicion: SCIE)
  • Área: INFECTIOUS DISEASES Cuartil: Q4 Posición en el área: 28/36 (Edicion: SCIE)

SCImago Journal Rank

  • Año 2000
  • Impacto SJR de la revista: 0.446
  • Cuartil mayor: Q1
  • Área: Medicine (miscellaneous) Cuartil: Q1 Posición en el área: 681/3043
  • Área: Microbiology (medical) Cuartil: Q2 Posición en el área: 30/100
  • Área: Infectious Diseases Cuartil: Q2 Posición en el área: 68/153
  • Área: Pharmacology (medical) Cuartil: Q2 Posición en el área: 54/173

Dimensions

(Datos actualizados a fecha de 30-03-2023)
  • Citas totales: 46
  • Citas recientes: 0
  • Relative Citation Ratio (RCR): 1.26
  • Field Citation Ratio (FCR): 3.16

Resumen

Aminoglycoside resistance was evaluated in 690 enterococcus strains isolated from different clinical sources originating from patients at the University Clinic Hospital of Zaragoza (Spain). The enterococci obtained from clinically significant samples (blood, urine, or exudates) showed more high- level resistance to gentamicin and streptomycin (65 and 42%, respectively) than those isolated from faecal samples (49 and 23%, respectively). Aminoglycoside-modifying enzymes (AME) from 119 of these high-level gentamicin and streptomycin resistant enterococcus strains were studied. The most frequent AMEs found were APH(3') and AAC(6')-APH(2''). More than one enzyme was detected in 71% of the strains (four different enzymes in 5% of the strains). Three Enterococcus faecalis strains had ANT(4')(4'') enzymatic activity. Different enzymatic expressions of the bifunctional enzyme AAC(6')- APH(2'') were demonstrated in strains in which the complete aac(6')-aph(2'') gene was detected by PCR and hybridization: (i) AAC(6') + APH(2'') activity; (ii) AAC(6') only; (iii) APH(2'') only; and (iv) no activity of AAC(6') or APH(2''). (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy.