Patogénesis del dolor en la mucositis oral. Revisión de la literatura

  1. Juan Francisco Peña Cardelles 1
  2. Ángel Orión Salgado Peralvo
  3. Naresh Kewalramani Kewalramani 1
  4. Iván García Guerrero 1
  5. Daniel Robles Cantero 1
  6. Rafael Gómez de Diego 1
  1. 1 Universidad Rey Juan Carlos

    Universidad Rey Juan Carlos

    Madrid, España


Científica dental: Revista científica de formación continuada

ISSN: 1697-6398

Argitalpen urtea: 2021

Alea: 18

Zenbakia: 1

Orrialdeak: 29-33

Mota: Artikulua

Beste argitalpen batzuk: Científica dental: Revista científica de formación continuada


Introduction: Oral mucositis is a painful lesion that occurs in the mucosa of the oral cavity. Its aetiology is usually associated with drug treatments in cancer patients. It presents as well-defined ulcers whose painful symptoms sometimes lead to the suspension of cancer treatment or parenteral nutrition. They therefore represent a significant adverse effect that marks the future in this type of cancer therapy. Objective: The objective of this article is to highlight how pain occurs in this pathology that takes place in the mucosa of the oral cavity. Discussion: Oral mucositis will occur following a cascade of biological events involving different molecular processes following treatment with chemotherapy or radiotherapy. Pain in oral mucositis may have an inflammatory component as well as a neuropathic component. In its pathophysiology, pain will be mediated by different families of receptors and factors. Conclusion: Oral mucositis has a large associated painful component, in which the families of TRP, ET-1, TNF and ROS receptors and factors, among others, play a major role in its appearance. Knowledge of the pathogenesis of the pain in this pathology will allow pain therapies to be developed in future studies.