Bisfenol (A) una toxina a tener en cuenta en el enfermo renal en hemodiálisis

  1. Bosch Panadero, Enrique
  2. Mas Fontao, Sebastian 1
  3. Ruiz Priego, Alberto 2
  4. Egido, Jesús 2
  5. González Parra, Emilio 3
  1. 1 Centro de Investigación Biomédica en Red en Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Madrid, España
  2. 2 Departamento de Nefrología e Hipertensión, Madrid, España, Red Española de Investigación Renal, Madrid, España
  3. 3 Facultad de Medicina, Universidad Autónoma de Madrid, España; Fundación Renal Íñigo Álvarez de Toledo, Instituto Reina Sofía de Investigación en Nefrología, Madrid, España
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Revista:
Revista Colombiana de Nefrología

ISSN: 2500-5006,  2389-7708

Año de publicación: 2017

Título del ejemplar: January - June 2017

Volumen: 4

Número: 1

Páginas: 57-68

Tipo: Artículo

DOI: 10.22265/ACNEF.4.1.256 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Revista Colombiana de Nefrología

Resumen

Muchas toxinas urémicas son originadas como consecuencia del catabolismo proteico por la flora intestinal. El metabolismo de aminoácidos aromáticos origina residuos de tipo fenólico. De estas toxinas, la más estudiada es el p-cresol, que se asocia a la función renal y daño vascular. El Bisfenol A (BPA) es una molécula exógena de características semejantes a estas toxinas urémicas aromáticas. El BPA es un disruptor endocrino estrogénico que se encuentra en latas de conserva, botellas de plástico, resinas epoxi y en algunos dializadores. Esta molécula se acumula en pacientes que tienen deteriorada la función renal. Estudios observacionales han demostrado que una exposición a BPA está vinculada, entre otras muchas, a lesión renal y cardiovascular en los seres humanos; en estudios en animales se ha descrito un vínculo causal. Los riñones con función renal normal excretan rápidamente BPA, pero una excreción insuficiente en pacientes con ERC da lugar a la acumulación del BPA en el organismo.

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Fuente de los datos: Dialnet