Esteban
Dominguez Manzanares
Publicaciones (22) Publicaciones de Esteban Dominguez Manzanares
2013
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GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models
Bioorganic and Medicinal Chemistry Letters, Vol. 23, Núm. 23, pp. 6459-6462
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GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy
Bioorganic and Medicinal Chemistry Letters, Vol. 23, Núm. 23, pp. 6463-6466
2006
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A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives
Bioorganic and Medicinal Chemistry Letters, Vol. 16, Núm. 19, pp. 5057-5061
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A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346
Bioorganic and Medicinal Chemistry Letters, Vol. 16, Núm. 19, pp. 5203-5206
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Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats
Journal of Pharmacology and Experimental Therapeutics, Vol. 319, Núm. 1, pp. 396-404
2005
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Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain
Journal of Medicinal Chemistry, Vol. 48, Núm. 13, pp. 4200-4203
2002
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Ethyl (3s,4aR,6S,8aR)-6-(4-ethoxycar-bonylimidazol-1-ylmethyl) decahydroiso-quinoline-3-carboxylic ester: A prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine
Journal of Medicinal Chemistry, Vol. 45, Núm. 20, pp. 4383-4386
2001
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Enantioselective solution- and solid-phase synthesis of glutamic acid derivatives via Michael addition reactions
Tetrahedron Asymmetry, Vol. 12, Núm. 6, pp. 821-828
2000
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Efficient synthesis of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides
Tetrahedron Letters, Vol. 41, Núm. 50, pp. 9825-9828
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Solid phase synthesis of glutamic acid derivatives via nucleophilic ring opening of N-Boc pyroglutamate with heteronucleophiles
Tetrahedron Letters, Vol. 41, Núm. 23, pp. 4567-4571
1998
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Solid-phase synthesis of substituted glutamic acid derivatives via Michael addition reactions
Tetrahedron Letters, Vol. 39, Núm. 15, pp. 2167-2170
1995
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1,3-Dipolar cycloaddition of enantiopure γ-oxygenated-α,β-unsaturated phenyl sulfones with nitrile oxides
Tetrahedron: Asymmetry, Vol. 6, Núm. 5, pp. 1035-1038
1994
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Flexible and stereoselective construction of polypropionate chains from enantiomerically pure γ-hydroxy-α,β-unsaturated sulfones
Tetrahedron, Vol. 50, Núm. 25, pp. 7557-7566
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Stereoselective approach to optically pure syn 2-amino alcohol derivatives
Tetrahedron Letters, Vol. 35, Núm. 26, pp. 4603-4606
1993
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A New Method for the Iterative Construction of Enantiomerically Pure Polypropionate Chains
Journal of Organic Chemistry
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Diastereoselectivity of the conjugate addition of organocopper reagents to (E)-γ-hydroxy-α,β-unsaturated sulfones
Tetrahedron Letters, Vol. 34, Núm. 36, pp. 5803-5806
1992
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Lipase-Catalyzed Kinetic Resolution of γ-Hydroxy Phenyl Sulfones
Journal of Organic Chemistry, Vol. 57, Núm. 14, pp. 3867-3873
1991
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An efficient preparation of optically active (E)-γ-hydroxy-α,β-unsaturated phenyl sulfones using lipase-mediated acylations
Tetrahedron Letters, Vol. 32, Núm. 38, pp. 5159-5162
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Synthesis and conjugate additions to (E)-γ-alkoxy-α-substituted-α,β-unsaturated sulfones
Tetrahedron Letters, Vol. 32, Núm. 10, pp. 1385-1388
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Synthesis and hydride reductions of chiral cyclic β-iminosulfoxides
Tetrahedron, Vol. 47, Núm. 48, pp. 10035-10044