Publications en collaboration avec des chercheurs de Eli Lilly and Company (11)

2013

  1. GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models

    Bioorganic and Medicinal Chemistry Letters, Vol. 23, Núm. 23, pp. 6459-6462

  2. GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

    Bioorganic and Medicinal Chemistry Letters, Vol. 23, Núm. 23, pp. 6463-6466

2006

  1. A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives

    Bioorganic and Medicinal Chemistry Letters, Vol. 16, Núm. 19, pp. 5057-5061

  2. A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346

    Bioorganic and Medicinal Chemistry Letters, Vol. 16, Núm. 19, pp. 5203-5206

  3. Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats

    Journal of Pharmacology and Experimental Therapeutics, Vol. 319, Núm. 1, pp. 396-404

2005

  1. Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain

    Journal of Medicinal Chemistry, Vol. 48, Núm. 13, pp. 4200-4203

2002

  1. Ethyl (3s,4aR,6S,8aR)-6-(4-ethoxycar-bonylimidazol-1-ylmethyl) decahydroiso-quinoline-3-carboxylic ester: A prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine

    Journal of Medicinal Chemistry, Vol. 45, Núm. 20, pp. 4383-4386

2001

  1. Enantioselective solution- and solid-phase synthesis of glutamic acid derivatives via Michael addition reactions

    Tetrahedron Asymmetry, Vol. 12, Núm. 6, pp. 821-828

2000

  1. Efficient synthesis of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides

    Tetrahedron Letters, Vol. 41, Núm. 50, pp. 9825-9828

  2. Solid phase synthesis of glutamic acid derivatives via nucleophilic ring opening of N-Boc pyroglutamate with heteronucleophiles

    Tetrahedron Letters, Vol. 41, Núm. 23, pp. 4567-4571

1998

  1. Solid-phase synthesis of substituted glutamic acid derivatives via Michael addition reactions

    Tetrahedron Letters, Vol. 39, Núm. 15, pp. 2167-2170