Effect of gingival application of melatonin on alkaline and acid phosphatase, osteopontin and osteocalcin in patients with diabetes and periodontal disease
- Antonio Cutando Soriano
- Antonio López-Valverde Centeno
- Rafael Gómez de Diego
- Salvador Arias Santiago
- Joaquín de Vicente Jiménez
ISSN: 1698-6946
Year of publication: 2013
Volume: 18
Issue: 4
Pages: 657-663
Type: Article
More publications in: Medicina oral, patología oral y cirugía bucal. Ed. inglesa
Metrics
Cited by
JCR (Journal Impact Factor)
- Year 2013
- Journal Impact Factor: 1.095
- Journal Impact Factor without self cites: 0.976
- Article influence score: 0.333
- Best Quartile: Q3
- Area: DENTISTRY, ORAL SURGERY & MEDICINE Quartile: Q3 Rank in area: 52/83 (Ranking edition: SCIE)
SCImago Journal Rank
- Year 2013
- SJR Journal Impact: 0.692
- Best Quartile: Q2
- Area: Otorhinolaryngology Quartile: Q2 Rank in area: 37/115
- Area: Medicine (miscellaneous) Quartile: Q2 Rank in area: 955/2999
- Area: Surgery Quartile: Q2 Rank in area: 122/441
- Area: Dentistry (miscellaneous) Quartile: Q2 Rank in area: 36/131
Scopus CiteScore
- Year 2013
- CiteScore of the Journal : 2.6
- Area: Dentistry (all) Percentile: 74
- Area: Surgery Percentile: 72
- Area: Otorhinolaryngology Percentile: 66
Abstract
Objectives: To assess the effect of topical application of melatonin to the gingiva on salivary fluid concentrations of acid phosphatase, alkaline phosphatase, osteopontin, and osteocalcin. Study Design: Cross-sectional study of 30 patients with diabetes and periodontal disease and 30 healthy subjects. Diabetic patients were treated with topical application of melatonin (1% orabase cream formula) once daily for 20 days and controls with a placebo formulation. Results: Before treatment with melatonin, diabetic patients showed significantly higher mean salivary levels of alkaline and acid phosphatase, osteopontin and osteocalcin than healthy subjects (P < 0.01). After treatment with melatonin, there was a statistically significant decrease of the gingival index (15.84± 10.3 vs 5.6 ± 5.1) and pocket depth (28.3 ± 19.5 vs 11.9 ± 9.0) (P < 0.001). Also, use of melatonin was associated with a significant reduction of the four biomarkers. Changes of salivary acid phosphatase and osteopontin correlated significantly with changes in the gingival index, whereas changes of alkaline phosphatase and osteopontin correlated significantly with changes in the pocket depth. Conclusions: Treatment with topical melatonin was associated with an improvement in the gingival index and pocket depth, a reduction in salivary concentrations of acid phosphatase, alkaline phosphatase, osteopontin and osteocalcin.