Regeneración ósea por medio de células madre en combinación con beta-fosfato tricálcico

  1. Leticia Blanco Antona 1
  2. María Begoña García Cenador
  3. María José Sánchez Ledesma
  4. Rosa Rojo López
  5. María Sandra Muntión Olave
  6. Francisco Collía Fernández
  7. J. De Vicente Jiménez
  8. Antonio López-Valverde Centeno
  1. 1 Universidad de Salamanca

    Universidad de Salamanca

    Salamanca, España



ISSN: 1888-6116

Year of publication: 2014

Volume: 25

Issue: 4

Pages: 237-244

Type: Article

More publications in: Trauma


Objective: To study whether adult mesenchymal stem cells in combination with a carrier of beta-tricalcium phosphate contributes significantly in regenerating bone injury in traumatized. Material and method: A traumatic defect model on the femur was used in Wistar rats (n=38). Two groups were designed: the group 1 (control) with 9 rats to which they there was realized a bone defect empty fault, and the group 2 (experimental), with three subgroups (2a, 2b, 2c) of 10 rat each, which were administered the carrier beta-tricalcium phosphate (β-TCP), and β-TCP in combination with mesenchymal stem cells (MSC). Results were valued to 3, 6 and 9 weeks of evolution, respectively. Results: There were 65% of the fractures in the right femur of rats in the experimental group that corresponds to the area where the carrier is implanted in combination with the MSC, but only 35% of these coincide exactly with this area. No significant differences in biological behavior, although it shows osteogenic activity. Conclusion: The use of β-TCP carrier in combination with mesenchymal stromal cells does not produce significant results in bone regeneration. There is a need for further research in experimental phase