MicroARNs en asmabiomarcadores de enfermedad asmática, fenotipos de gravedad y posibles herramientas terapéuticas

Abstract

Asthma is a chronic respiratory disease of the airways characterized by coughing, wheezing and breathing difficulty, caused by an exacerbation of physiological inflammatory responses. In particular, the main cells involved in this disease belong to, both adaptive immunity, such as helper lymphocytes, T and B cells; and innate immunity, including dendritic cells, macrophages, or eosinophils, which are particularly important in asthma. Eosinophils are granulocytes capable of inducing pro-inflammatory responses through the release of their granules and exosomes. Particularly, exosomes are extracellular vesicles secreted by cells that are capable of affecting the behaviour of cells who receive them. This intercellular communication is mediated by proteins and nucleic acids, like microRNAs (miRNAs), which are encapsulated inside exosomes...