Introducción al sistema inmune. Componentes celulares del sistema inmune innato

  1. Monserrat Sanz, J.
  2. Sosa Reina, M.D.
  3. Prieto Martín, A.
Revista:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Any de publicació: 2017

Sèrie: 12

Número: 24

Pàgines: 1369-1378

Tipus: Article

DOI: 10.1016/J.MED.2016.12.006 DIALNET GOOGLE SCHOLAR

Altres publicacions en: Medicine: Programa de Formación Médica Continuada Acreditado

Resum

AbstractIntroduction to the immune system Our body is exposed to pathogenic microorganisms that try to colonize us, cause illness and even compromise our survival. Immune system is the physiological tool consists of a set of molecules, cells and tissues that defend us from attacks caused by pathogens or tumors. In this chapter the relevance of the immune system to ensure our survival is addressed. The innate immune system It represents the first line of defense and it is responsible for quick and efficient responses to pathogens. It provides the time needed to activate the adaptive system and expand and select the best defense to finish them. Cellular components of the innate immune system To perform its defensive function, innate immune system is aided by a set of specialized cells: granulocytes, including neutrophils, leading advocates against fagocitables pathogens, bacteria and fungi, and eosinophils and basophils, which protect us from parasites not phagocitables and helminths. Monocytes, macrophages and dendritic cells destroy microorganisms, processing and presenting them to the adaptive system. Natural killer cells are responsible for eliminating virus-infected cells or tumors.

Referències bibliogràfiques

  • Parkin J, Cohen B. An overview of the immune system. Lancet. 2001;357(9270):1777-89.
  • Bonilla FA, Oettgen HC. Adaptive immunity. J Allergy Clin Immunol 2010;125(2)Suppl2:S33-S40.
  • Sanz E, Muñoz A, Monserrat J, Van Den Rym A, Escoll P, Ranz I. Ordering human CD34+CD10-CD19+ pre/pro-B-cell and. Proc Natl Acad Sci U S A 2010;107(13):5925-30.
  • Witko-Sarsat V, Rieu P, Descamps-Latscha B, Lesavre P, Halb-wachs-Mecarelli L. Neutrophils: molecules, functions and patho-physiological aspects. Lab Invest.;80(5):617-53.
  • Von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med. 2000;343(14):1020-34.
  • Levay PF, Viljoen M. Lactoferrin: a general review. Haematologica. 1995;80(3):252-67.
  • Abbas AK, Lichtman AH, Pillai S. Cells and tissues of immune system. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier; 2015. p. 15-37.
  • Male D, Brostoff J, Roth D, Roitt I. Celulas, téjidos y órganos del sistema inmunitario. Inmunología. 8ª ed. Barcelona: Elsevier; 2014. p. 17-51.
  • Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol. 2010;125(2)Suppl2:S73-S80.
  • Paul WE. The immune system. 7ª ed. En: Paul WE, editor. Fundamental immunology. Philadelphia: Lippincott Williams and Wilkins; 2013. p. 1214-60
  • Rottem M, Okada T, Goff JP, Metcalfe DD. Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/Fc epsilon RI- cell population. Blood. 1994;84(8): 2489-96.
  • Agis H, Willheim M, Sperr WR, Wilfing A, Kromer E, Kabrna E. Monocytes do not make mast cells when cultured in the presence of SCF. Characterization of the circulating mast cell progenitor as a c-kit+, CD34+, Ly-, CD14-, CD17-, colony-forming cell. J Immunol. 1993; 151(8):4221-7.
  • Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2(8):675-80.
  • Castells MC, Klickstein LB, Hassani K, Cumplido JA, Lacouture ME, Austen KF. gp49B1-alpha(v)beta3 interaction inhibits antigen- induced mast cell activation. Nat Immunol. 2001;2(5):436-42.
  • Lauvau G, Loke P, Hohl TM. Monocytemediated defense against bacteria, fungi, and parasites. Semin Immunol. 2015;27(6):397-409.
  • Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014;14(6): 392-404.
  • Auffray C, Sieweke MH, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol. 2009;27:669-92.
  • Hasan D, Chalouhi N, Jabbour P, Hashimoto T. Macrophage imbalance (M1 vs. M2) and upregulation of mast cells in wall of ruptured human cerebral aneurysms: preliminary results. J Neuroinflammation. 2012;9:222.
  • Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003;19(1):71-82.
  • Hume DA, Summers KM, Rehli M. Transcriptional Regulation and Macrophage Differentiation. Microbiol Spectr. 2016;4(3).
  • Huang Q, Ma Y, Adebayo A, Pope RM. Increased macrophage activation mediated through toll-like receptors in rheumatoid arthritis. Arthritis Rheum. 2007;56(7):2192-201.
  • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012;122(3):787-95.
  • Mantovani A, Locati M. Tumor associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions. Arterioscler Thromb Vasc Biol. 2013;33(7):1478-83.
  • Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11(11):723-37.
  • Hespel C, Moser M. Role of inflammatory dendritic cells in innate and adaptive immunity. Eur J Immunol. 2012;42(10):2535-43.
  • Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med. 1973;137(5):1142-62.
  • Zhou T, Chen Y, Hao L, Zhang Y. DC-SIGN and immunoregulation. Cell Mol Immunol. 2006;3(4):279-83.
  • Jaitley S, Saraswathi T. Pathophysiology of Langerhans cells. J Oral Maxillofac Pathol. 2012;16(2):239-44.
  • Van Nierop K, de Groot C. Human follicular dendritic cells: function, origin and development. Semin Immunol. 2002;14(4):251-7.
  • Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol. 2000;165(11):6037-46.
  • Gupta MR, Kolli D, Garofalo RP. Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syn-cytial virus infection. Respir Res. 2013;14:71
  • MacDonald KP, Munster DJ, Clark GJ, Dzionek A, Schmitz J, Hart DN. Characterization of human blood dendritic cell subsets. Blood. 2002; 100(13):4512-20.
  • Miles B, Abdel-Ghaffar KA, Gamal AY, Baban B, Cutler CW. Blood dendritic cells: «canary in the coal mine» to predict chronic inflammatory disease? Front Microbiol. 2014;5:6.
  • Moret FM, Hack CE, van der Wurff-Jacobs KM, de JW, Radstake TR, Lafeber FP. Intra-articular CD1c-expressing myeloid dendritic cells from rheumatoid arthritis patients express a unique set of T cell-attract-ing chemokines and spontaneously induce Th1, Th17 and Th2 cell activ-ity. Arthritis Res Ther. 2013;15(5):R155.
  • Piccioli D, Tavarini S, Borgogni E, Steri V, Nuti S, Sammicheli C. Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets. Blood. 2007;109(12):5371-9.
  • De Landazuri MO, López-Botet M, Timonen T, Ortaldo JR, Herberman RB. Human large granular lymphocytes: spontaneous and interferon-boosted NK activity against adherent and nonadherent tumor cell lines. J Immunol. 1981;127(4):1380-3.
  • Timonen T, Ortaldo JR, Herberman RB. Characteristics of human large granular lymphocytes and relationship to natural killer and K cells. J Exp Med. 1981;153(3):569-82.
  • Moretta L, Bottino C, Pende D, Mingari MC, Biassoni R, Moretta A. Human natural killer cells: their origin, receptors and function. Eur J Immunol. 2002;32(5):1205-11.
  • Sivori S, Falco M, Marcenaro E, Parolini S, Biassoni R, Bottino C. Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc Natl Acad Sci U S A. 2002;99(7):4526-31
  • Juelke K, Killig M, Luetke-Eversloh M, Parente E, Gruen J, Morandi B. CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells. Blood. 2010;116(8):1299-307.
Fuente de los datos: Dialnet