Capacidad antiséptica del digluconato de clorhexidina 0,05% y cloruro de cetilpiridinio 0,05%. Estudio clínico prospectivo y microbiológico

  1. Alvaro Zubizarreta Macho
  2. Luis Oscar Alonso Ezpeleta
  3. Carlos Gutiérrez-Ortega 1
  4. Juan Ramón Maestre Vera
  1. 1 Universidad Alfonso X el Sabio

    Universidad Alfonso X el Sabio

    Villanueva de la Cañada, España


Científica dental: Revista científica de formación continuada

ISSN: 1697-6398 1697-641X

Year of publication: 2019

Volume: 16

Issue: 1

Pages: 7-15

Type: Article

More publications in: Científica dental: Revista científica de formación continuada


Introduction: The aim of this study was to evaluate the clinical and microbiological efficacy of a mouthrinse containing 0.05% chlorhexidine digluconate (CHX) and 0.05% cetylpyridinium chloride (CPC), and another mouthrinse without antiseptic properties, used as adjuvants to oral hygiene methods. Material and methods: First a microbiological study using spectrophotometry as done to inhibit the formation and adhesion of an Streptococus oralis biofilm, Then, a randomised, double-blind clinical trial as performed on a saple of 48 patients, who were randomly assigned to each mouthrinse. A: 0.05% CHC and 0.05% CPC, and B: 0.10% permethol and 0.50% provitamin B5. Plaque index (PI), modified gingival index (MGI) and bleeding index (BI) were assessed at one and three months. Results: The 0.05% CHX 0.05% CPC mouthrinse showed a high cpacity to inhibit the formation (P = 0.013) and adhesion (P = 0.001) of the bacterial biofilm. Statistically significant differences were observed in the inter-group PI after three months of monitoring (P <0.001). Differences were also observed in MGI after one month (P = 0,034) and after three months of monitoring (P <0,001); and in BI after one month (P = 0,004) and after three months of observation (P = 0,002). Conclusions: The 0.05% CHX and 0.05% CPC mouthrinse has a good cpacity to reduce bacterial plaque and gingivitis.