Factores de riesgo asociados con el grosor íntima-media y la presencia de placas en arteria carótidaEstudio ESPREDIA
- Mostaza, Jose M.
- Lahoz, Carlos
- Salinero-Fort, Miguel A.
- Laguna, Fernando
- Estirado, Eva
- García-Iglesias, Francisca
- González Alegre, Teresa
- Sabín, Concesa
- López, Silvia
- Cornejo, Victor
ISSN: 0214-9168, 1578-1879
Datum der Publikation: 2018
Ausgabe: 30
Nummer: 2
Seiten: 49-55
Art: Artikel
Andere Publikationen in: Clínica e investigación en arteriosclerosis
Zusammenfassung
Objective To evaluate whether there were any differences in the risk factor profile associated with either the intima-media thickness (IMT) or the presence of carotid plaques. Methods Cross-sectional study in 1475 subjects between 45 and 75 years, randomly selected from the population of the Northwest area of Madrid (Spain). They had a physical exam, blood analysis, and ultrasound measurement of the IMT and of the presence of plaques. Results Mean IMT was 0.725 ± 0.132 mm. Forty seven percent of the participants had carotid plaques. In multivariate analysis, factors directly associated with the IMT were, age (β 0.227, P < .0001), sex (β 0.104, P < .0001), presence of hypertension (β 0.082, P = .002), diabetes (β 0.130, P < .0001) and current smoking (β 0.107, P < .0001), systolic blood pressure (SBP) (β 0.219, P < .0001) and LDL-cholesterol levels (β 0.074, P = .003), and inversely, diastolic blood pressure (DBP) (β −0.124, P = .001), HDL-cholesterol (β −0.111, P < .0001) and triglyceride levels (β −0.060, P = .028). The presence of plaques was directly associated with age (OR 1.08; 95% CI: 1.05-1.10), sex (OR 1.95; 95% CI: 1.52-2.51), current smoking (OR 2.75; 95% CI: 1.92-3.95), history of hypertension (OR 1.58; 95% CI: 1.22-2.04) or diabetes (OR 1.84; 95% CI: 1.31-2.58), statin treatment (OR 1.56; 95% CI: 1.19-2.04) and SBP (OR 1.03; 95% CI: 1.02-1.05), and inversely with DBP (OR 0.98; 95% CI: 0.96-0.99). Conclusion Factors associated with the IMT and the presence of plaques are similar, a finding that support a continuum between muscular layer hypertrophy and arteriosclerosis development.