Prospective Association Between Plasma Amino Acids and Multimorbidity in Older Adults

  1. Caballero, Francisco Félix 1
  2. Lana, Alberto 3
  3. Struijk, Ellen A 1
  4. Arias-Fernández, Lucía 8
  5. Yévenes-Briones, Humberto 1
  6. Cárdenas-Valladolid, Juan 4910
  7. Salinero-Fort, Miguel Ángel 4567
  8. Banegas, José R 1
  9. Rodríguez-Artalejo, Fernando 12
  10. Lopez-Garcia, Esther 12
  1. 1 Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid and CIBER of Epidemiology and Public Health , Madrid , Spain
  2. 2 IMDEA-Food Institute, CEI UAM+CSIC , Madrid , Spain
  3. 3 Department of Medicine, Universidad de Oviedo/ISPA , Oviedo , Spain
  4. 4 Fundación de Investigación e Innovación Biosanitaria de Atención Primaria , Madrid , Spain
  5. 5 Subdirección General de Investigación Sanitaria, Consejería de Sanidad , Madrid , Spain
  6. 6 Red de Investigación en Servicios de Salud en Enfermedades Crónicas , Madrid, Spain
  7. 7 Grupo de Envejecimiento y Fragilidad de las personas mayores, IdIPAZ , Madrid , Spain
  8. 8 Primary Health Care Network, Asturias Health Service , Asturias , Spain
  9. 9 Dirección Técnica de Sistemas de Información, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de Salud , Madrid , Spain
  10. 10 Enfermería, Universidad Alfonso X El Sabio , Villanueva de la Cañada , Spain
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Revista:
The Journals of Gerontology: Series A

ISSN: 1079-5006,  1758-535X

Año de publicación: 2022

Tipo: Artículo

DOI: 10.1093/GERONA/GLAC144 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: The Journals of Gerontology: Series A

Resumen

BackgroundSome amino acids have been associated with aging-related disorders and risk of physical impairment. The aim of this study was to assess the association between plasma concentrations of 9 amino acids, including branched-chain and aromatic amino acids, and multimorbidity.MethodsThis research uses longitudinal data from the Seniors-ENRICA 2 study, a population-based cohort from Spain that comprises noninstitutionalized adults older than 65. Blood samples were extracted at baseline and after a follow-up period of 2 years for a total of 1 488 subjects. Participants’ information was linked with electronic health records. Chronic diseases were grouped into a list of 60 mutually exclusive conditions. A quantitative measure of multimorbidity, weighting morbidities by their regression coefficients on physical functioning, was employed and ranged from 0 to 100. Generalized estimating equation models were used to explore the relationship between plasma amino acids and multimorbidity, adjusting for sociodemographics, socioeconomic status, and lifestyle behaviors.ResultsThe mean age of participants at baseline was 73.6 (SD = 4.2) years, 49.6% were women. Higher concentrations of glutamine (coef. per mmol/l [95% confidence interval] = 10.1 [3.7, 16.6]), isoleucine (50.3 [21.7, 78.9]), and valine (15.5 [3.1, 28.0]) were significantly associated with higher multimorbidity scores, after adjusting for potential confounders. Body mass index could have influenced the relationship between isoleucine and multimorbidity (p = .016).ConclusionsAmino acids could play a role in regulating aging-related diseases. Glutamine and branched-chain amino acids as isoleucine and valine are prospectively associated and could serve as risk markers for multimorbidity in older adults.

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