Infección articular por Staphylococcus aureus.Características fenotípicas y genotípicas y correlación clínica

Resum

Prosthetic joint infection (PJI) and native arthritis produce significant morbidity. They require complex medical and surgical treatment, with treatment failure being high. Staphylococcus aureus is one of the main pathogens causing joint infection. It has numerous virulence genes encoding for adhesins or biofilm-forming proteins, which make antibiotic treatment difficult. One of the main virulence regulators of S. aureus is the accessory gene regulator (agr). There are not many studies that have delved into the microbiological and molecular characteristics of staphylococci in this infection, and even less in the association of these with the clinical outcome. The objective of this doctoral thesis was to characterize clinically, microbiologically and molecularly the joint infection caused by S. aureus and to explore the association of the phenotypic and genotypic characteristics of the bacterium with the clinical presentation and outcome of patients...