Concentración de colesterol-HDL y riesgo de infección por SARS-CoV-2 en personas mayores de 75 añosuna cohorte con medio millón de participantes de la Comunidad de Madrid

  1. Lahoz, Carlos
  2. Salinero-Fort, Miguel A. 1
  3. Cárdenas, Juan 2
  4. Rodríguez-Artalejo, Fernando
  5. Díaz-Almiron, Mariana 3
  6. Vich-Pérez, Pilar 1
  7. San Andrés-Rebollo, F. Javier 1
  8. Vicente, Ignacio 1
  9. Mostaza, José M. 4
  1. 1 Fundación para la Investigación e Innovación Biosanitaria de Atención Primaria (FIIBAP), Madrid, España
  2. 2 Dirección Técnica de Sistemas de Información Sanitaria, Gerencia Adjunta de Procesos Asistenciales, Gerencia Asistencial de Atención Primaria, Madrid, España
  3. 3 Unidad de Investigación, Hospital La Paz Instituto de investigación Sanitaria, IdiPAZ, Madrid, España
  4. 4 Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Carlos III, Madrid, España
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Journal:
Clínica e investigación en arteriosclerosis

ISSN: 0214-9168,  1578-1879

Year of publication: 2022

Volume: 34

Issue: 3

Pages: 113-119

Type: Article

DOI: HTTPS://DOI.ORG/10.1016/J.ARTERI.2021.11.006 DIALNET GOOGLE SCHOLAR

More publications in: Clínica e investigación en arteriosclerosis

Abstract

Objective The aim of this study was to analyze the relationship between HDL-cholesterol and the risk of SARS-CoV-2 infection in over 75-year-olds residing in the Community of Madrid. Methods Study of a population-based cohort, composed of all residents in Madrid (Spain) born before January 1, 1945 and alive on December 31, 2019. Demographic, clinical and analytical data were obtained from primary care electronic medical records from January 2015. Confirmed SARS-CoV-2 infection was defined as a positive RT-PCR or antigen test result. Infection data correspond to the period March 1, 2020 through December 31, 2020. Results Of the 593,342 cohort participants, 501,813 had at least one HDL-cholesterol determination in the past 5 years. Their mean age was 83.4 ± 5.6 years and 62.4% were women. A total of 36,996 (7.4%) had a confirmed SARS-CoV2 infection during 2020. The risk of infection [odds ratio (95% confidence interval)] for SARS-CoV2 according to increasing quintiles of HDL-cholesterol was 1, 0.960 (0.915-1.007), 0.891 (0.848-0.935), 0.865 (0.824-0.909) and 0.833 (0.792-0.876), after adjusting for age, sex, cardiovascular risk factors and comorbidities. Conclusions There is an inverse and dose-dependent relationship between HDL-cholesterol concentration and the risk of SARS-CoV2 infection in subjects aged over 75 years of age in the Community of Madrid.

Data source: Dialnet