Aplicaciones del suero autólogo en oftalmología

  1. J.S. López-García
  2. I. García-Lozano
  3. L. Rivas
  4. J. Martínez-Garchitorena
Revista:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Año de publicación: 2007

Volumen: 82

Número: 1

Páginas: 9-20

Tipo: Artículo

DOI: 10.4321/S0365-66912007000100004 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Archivos de la Sociedad Española de Oftalmologia

Resumen

Objetivo: Establecer un protocolo razonado para la preparación y manejo de la terapia con suero autólogo en la práctica oftalmológica. Métodos: Revisión bibliográfica y experiencia personal. Resultados: La utilización de suero autólogo en colirio ha sido referida por muchos autores como una nueva forma de terapia en el manejo de enfermedades de la superficie ocular. El suero autólogo presenta unas propiedades mecánicas y bioquímicas similares a las de la lágrima, y como ésta contiene componentes como la fibronectina, vitamina A y factores de crecimiento que tienen un efecto epiteliotrófico sobre las células epiteliales de la superficie ocular. Conclusiones: Los distintos estudios publicados muestran una importante variabilidad tanto en la eficacia de esta terapia como en la metodología de preparación y aplicación.

Referencias bibliográficas

  • Fox, RI, Chan, R, Michelson, JB, Belmont, JB, Michelson, PE. (1984). Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. Arthritis Rheum. 27. 459-461
  • Tsubota, K, Goto, E, Shimmura, S, Shimazaki, J. (1999). Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmolgy. 106. 1984-1989
  • Tsubota, K, Goto, E, Fujita, H, Ono, M, Inoue, H, Saito, I. (1999). Treatment of dry eye by autologous serum aplicattion in Sjogren`s syndrome. Br J Ophthalmol. 83. 390-395
  • Tseng, SC, Tsubota, K. (1997). Important concepts for treating ocular surface and tear disorders. Am J Ophthalmol. 124. 825-835
  • Wilson, SE, Liang, Q, Kim, WJ. (1999). Lacrimal gland HGF, KGF and EGF mRNA levels increase after corneal epithelial wounding. Invest Ophthalmol Vis Sci. 40. 2185-2190
  • Barton, K, Nava, A, Monroy, DC, Pflugfelder, SC. (1998). Cytokines and tear function in ocular surface disease. Adv Exp Med Biol. 438. 461-469
  • Geerling, G, Maclennan, S, Hartwig, D. (2004). Autologous serum eye drops for ocular surface disorders. Br J Ophthalmol. 88. 1467-1474
  • Gobbels, M, Spitznas, M. (1992). Corneal epithelial permeability of dry eyes before and after treatment with artificial tears. Ophthalmology. 99. 873-878
  • Burstein, NL. (1985). The effects of topical drugs and preservatives on the tears and corneal epithelium in dry eye. Trans Ophthalmol Soc UK. 104. 402-409
  • Geerling, G, Sieg, P, Meyer, C, Bastian, GO, Laqua, H. (1998). Transplantation of autologous submandibular glands in very severe keratoconjunctivitis sicca: 2 year outcome. Ophthalmologe. 95. 257-265
  • Vajpayee, RB, Mukerji, N, Tandon, R, Sharma, N, Pandey, RM, Biswas, NR. (2003). Evaluation of umbilical cord serum therapy for persistent corneal epithelial defects. Br J Ophthalmol. 87. 1312-1316
  • Borderie, VM, Mourra, N, Laroche, L. (1999). Influence of fetal calf serum, fibroblast growth factors, and hepatocyte growth factor on three-dimensional cultures of human keratocytes in collagen gel matrix. Graefes Arch Clin Exp Ophthalmol. 237. 861-869
  • Kirschner, SE. (1990). Persistent corneal ulcers: What to do when ulcers won´t heal. Vet Clin North Am Small Anim Pract. 20. 627-642
  • Alvarado Valero, MC, Martinez Toldos, JJ, Borras Blasco, J, Alminana Alminana, A, Perez Ramos, JM. (2004). Tratamiento de defectos epiteliales persistentes mediante suero autólogo. Arch Soc Esp Oftalmol. 79. 537-542
  • Kruse, FE, Tseng, SC. (1993). Serum differentially modulates the clonal growth and differentiation of cultured limbal and corneal epithelium. Invest Ophthalmol Vis Sci. 34. 2976-2989
  • van Setten, GB, Tervo, T, Tervo, K, Tarkkanen, A. (1992). Epidermal growth factor (EGF) in ocular fluids: presence, origin and therapeutical considerations. Acta Ophthalmol Suppl. 202. 54-59
  • Pastor, JC, Calonge, M. (1992). Epidermal growth factor and corneal wound healing: A multicenter study. Cornea. 11. 311-314
  • Collins, MK, Perkins, GR, Rodriguez-Tarduchy, G, Nieto, MA, Lopez-Rivas, A. (1994). Growth factors as survival factors: regulation of apoptosis. Bioessays. 16. 133-138
  • Rodeck, U, Jost, M, Kari, C, Shih, DT, Lavker, RM, Ewert, DL. (1997). EGF-R dependent regulation of keratinocyte survival. J Cell Sci. 110. 113-121
  • Ohashi, Y, Motokura, M, Kinoshita, Y, Mano, T, Watanabe, H, Kinoshita, S. (1989). Presence of epidermal growth factor in human tears. Invest Ophthalmol Vis Sci. 30. 1879-1882
  • Gupta, A, Monroy, D, Ji, Z, Yoshino, K, Huang, A, Pflugfelder, SC. (1996). Transforming growth factor beta-1 and beta-2 in human tear fluid. Curr Eye Res. 15. 605-614
  • Fredj-Reygrobellet, D, Plouet, J, Delayre, T, Baudouin, C, Bourret, F, Lapalus, P. (1987). Effects of aFGF and bFGF on wound healing in rabbit corneas. Curr Eye Res. 6. 1205-1209
  • Yoshino, K, Garg, R, Monroy, D, Ji, Z, Pflugfelder, SC. (1996). Production and secretion of transforming growth factor beta (TGF-beta) by the human lacrimal gland. Curr Eye Res. 15. 615-624
  • Wilson, SE, Lloyd, SA, Kennedy, RH. (1991). Basic fibroblast growth factor (FGFb) and epidermal growth factor (EGF) receptor messenger RNA production in human lacrimal gland. Invest Ophthalmol Vis Sci. 32. 2816-2820
  • Shimmura, S, Ueno, R, Matsumoto, Y, Goto, E, Higuchi, A, Shimazaki, J. (2003). Albumin as a tear supplement in the treatment of severe dry eye. Br J Ophthalmol. 87. 1279-1283
  • Poon, AC, Geerling, G, Dart, JK, Fraenkel, GE, Daniels, JT. (2001). Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies. Br J Ophthalmol. 85. 1188-1197
  • Nishida, T, Ohashi, Y, Awata, T, Manabe, R. (1983). Fibronectin: A new therapy for corneal trophic ulcer. Arch Ophthalmol. 101. 1046-1048
  • Phan, TM, Foster, CS, Shaw, CD, Zagachin, LM, Colvin, RB. (1991). Topical fibronectin in an alkali burn model of corenal ulceration in rabbits. Arch Ophthalmol. 109. 414-419
  • Nishida, T, Nakamura, M, Ofuji, K, Reid, TW, Mannis, MJ, Murphy, CJ. (1996). Synergistic effects of substance P with insulin-like growth factor-1 on epithelial migration of the cornea. J Cell Physiol. 169. 159-166
  • Lagnado, R, King, AJ, Donald, F, Dua, HS. (2004). A protocol for low contamination risk of autologous serum drops in the management of ocular surface disorders. Br J Ophthalmol. 88. 464-465
  • Tananuvat, N, Daniell, M, Sullivan, LJ, Yi, Q, McKelvie, P, McCarty, DJ. (2001). Controlled study of the use of autologous serum in dry eye patients. Cornea. 20. 802-806
  • Malavazzi, GR, Lake, JC, Dantas, PE. (2005). Effect of honey and autologous serum on corneal epithelial healing in rabbits. Arq Bras Oftalmol. 68. 347-351
  • Noble, BA, Loh, RS, MacLennan, S, Pesudovs, K, Reynols, A, Bridges, LR. (2004). Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease. Br J Ophthalmol. 88. 647-652
  • Pasternak, AS, Miller, WM. (1995). First-order toxicity assays for eye irritation using cell lines: parameters that affect in vitro evaluation. Fundam Appl Toxicol. 25. 253-263
  • Wang, XM, Terasaki, PI, Rankin, GW jr, Chia, D, Zhong, HP, Haardy, S. (1993). A new microcellular cytotoxicity test based on calcein AM release. Hum Immunol. 37. 264-270
  • Geerling, G, Daniels, JT, Dart, JK, Cree, IA, Khaw, PT. (2001). Toxicity of natural tear substitutes in a fully defined culture model of human corneal epithelial cells. Invest Ophthalmol Vis Sci. 42. 948-956
  • You, L, Ebner, S, Kruse, FE. (2001). Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells. Invest Ophthalmol Vis Sci. 42. 2496-2504
  • Voak, D, Cann, R, Finney, RD, Fraser, ID, Mitchell, R, Murphy, MF. (1994). Guidelines for administration of blood products: transfusion of infants and neonates. Transfus Med. 4. 63-69
  • Liu, L, Hartwig, D, Harloff, S, Herminghaus, P, Wedel, T, Geerling, G. (2005). An optimised protocol for the production of autologous serum eyedrops. Graefes Arch Clin Exp Ophthalmol. 243. 706-714
  • Garcia Jimenez, V, Veiga Villaverde, B, Baamonde Arbaiza, B, Cahue Carpintero, I, Celemin Vinuela, ML, Simo Martinez, RM. (2003). The elaboration, use and evaluation of eye-drops with autologous serum in corneal lesions. Farm Hosp. 27. 21-25
  • Sitaramamma, T, Shivaji, S, Rao, GN. (1998). Effect of storage on protein concentration of tear samples. Curr Eye Res. 17. 1027-1035
  • Mukerji, N, Sinha, R, Vajpayee, RB. (2002). Role of autologous serum in persistent epithelial defects. Br J Ophthalmol. 86. 832
  • Sauer, R, Bluthner, K, Seitz, B. (2004). Sterility of non-preserved autologous serum drops for treatment of persistent corneal epithelial defects. Ophthalmologe. 101. 705-709
  • Nakamura, M, Nishida, T, Mishima, H, Otori, T. (1993). Effects of antimicrobials on corneal epithelial migration. Curr Eye Res. 12. 733-740
  • Young, AL, Cheng, AC, Ng, HK, Cheng, LL, Leung, GY, Lam, DS. (2004). The use of autologuos serum tears in persistent corneal epithelial defects. Eye. 18. 609-614
  • Pfister, RR. (1992). Clinical measures to promote corneal epithelial healing. Acta Ophthalmol Suppl. 202. 73-83
  • Ali, Z, Insler, MS. (1986). A comparison of therapeutic bandage lenses, tarsorrhaphy, and antibiotic and hypertonic saline on corneal epithelial wound healing. Ann Ophthalmol. 18. 22-24
  • Panda, A, Pushker, Bageshwar, LM. (1999). Lateral tarsorrhaphy: is it preferable to patching?. Cornea. 18. 299-301
  • Azuara-Blanco, A, Pillai, CT, Dua, HS. (1999). Amniotic membrane transplantation for ocular surface reconstruction. Br J Ophthalmol. 83. 399-402
  • Tan, DT, Ficker, LA, Buckley, RJ. (1996). Limbal transplantation. Ophthalmology. 103. 29-36
  • Gordon, JF, Johnson, P, Musch, DC. (1995). Topical fibronectin ophthalmic solution in the treatment of persistent defects of the corneal epithelium. Am J Ophthalmol. 119. 281-287
  • Ralph, RA. (2000). Tetracyclines and the treatment of corneal stromal ulceration: a review. Cornea. 19. 274-277
  • Pellegrini, G, Traverso, CE, Franzi, AT, Zingirian, M, Cancedda, R, De Luca, M. (1997). Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet. 349. 990-993
  • Díaz-Valle, D, Benítez del Castillo Sánchez, JM, Díaz Rodríguez, E, Toledano Fernández, N, Arteaga Sánchez, A, Sayagues Gómez, O. (2003). Manejo de la queratopatía neurotrófica mediante tarsorrafia con cianoacrilato y suero autólogo. Arch Soc Esp Oftalmol. 78. 119-122
  • Matsumoto, Y, Dogru, M, Goto, E, Ohashi, Y, Kojima, T, Ishida, R, Tsubota, K. (2004). Autologous serum application in the treatment of neurotrophic keratopathy. Ophthalmology. 111. 1115-1120
  • del Castillo, JM, de la Casa, JM, Sardina, RC, Fernandez, RM, Feijoo, JG, Gomez, AC. (2002). Treatment of recurrent corneal erosions using autologous serum. Cornea. 21. 781-783
  • Tsubota, K, Satake, Y, Ohyama, M, Toda, I, Takano, Y, Ono, M. (1996). Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. Am J Ophthalmol. 122. 38-52
  • Ogawa, Y, Okamoto, S, Mori, T, Yamada, M, Mashima, Y, Watanabe, R. (2003). Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transplant. 31. 579-583
  • Rocha, EM, Pelegrino, FS, de Paiva, CS, Vigorito, AC, de Souza, CA. (2000). GVDH dry eyes treated with autologous serum tears. Bone Marrow Transplant. 25. 1101-1103
  • Goto, E, Shimmura, S, Shimazaki, J, Tsubota, K. (2001). Treatment of superior limbic keratoconjunctivitis by application of autologous serum. Cornea. 20. 807-810
  • Matsuo, H, Tomidokoro, A, Tomita, G, Araie, M. (2005). Topical application of autologous serum for the treatment of late-onset aqueous oozing or point-leak through filtering bleb. Eye. 19. 23-28
  • Liggett, PE, Skolik, DS, Horio, B, Saito, Y, Alfaro, V, Mieler, W. (1995). Human autologous serum for the treatment of full-thickness macular holes. A preliminary study. Ophthalmology. 102. 1071-1076
  • Nakamura, H, Hayakawa, K, Sawaguchi, S, Gaja, T. (2005). Removal of retinal indocyanine green dye by autologous serum irrigation in macular hole surgery. Retina. 25. 736-741
  • Christmas, NJ, Skolik, SA, Howard, MA, Saito, Y, Barnstable, CJ, Liggett, PE. (1995). Treatment of retinal breaks with autologous serum in an experimental model. Ophthalmology. 102. 263-271
  • Cullinane, AB, O´Callaghan, P, McDermott, K, Keohane, C, Cleary, PE. (2002). Effects of autologous platelet concentrate and serum on retinal wound healing in an animal model. Graefes Arch Clin Exp Ophthalmol. 240. 35-41
  • McDonnell, PJ, Schanzlin, DJ, Rao, NA. (1988). Immunoglobulin deposition in the cornea after application of autologous serum. Arch Ophthalmol. 106. 1423-1425
  • Eberle, J, Habermann, J, Gurtler, LG. (2000). HIV-1 infection transmitted by serum droplets into the eye: a case report. AIDS. 14. 206-207
  • Yokoi, N, Komuro, A, Nishida, K, Kinoshita, S. (1997). Effectiveness of hyaluronan on corneal epithelial barrier function in dry eye. Br J Ophthalmol. 81. 533-536
  • Nelson, JD, Drake, MM, Brewer, JT Jr, Tuley, M. (1994). Evaluation of a physiological tear substitute in patients with keratoconjunctivitis sicca. Adv Exp Med Biol. 350. 453-457
  • Nelson, JD, Gordon, JF. (1992). Topical fibronectin in the treatment of keratoconjunctivitis sicca. Am J Ophthalmol. 114. 441-447
Fuente de los datos: Dialnet