Compresión medular por sarcoma granulocítico primario

  1. Eduardo García Romo 1
  2. Eva Yebra Fernández 2
  3. Ramón Rodríguez González 2
  4. José Luis Agud Aparicio 2
  5. Rosalía Riaza Grau 2
  6. Beatriz Valle Borrego 2
  7. Fernando Burgos Lázaro 2
  1. 1 Hospital Fundación Jiménez Díaz
  2. 2 Hospital Severo Ochoa
    info

    Hospital Severo Ochoa

    Madrid, España

    ROR https://ror.org/05s3h8004

Revista:
Revista Colombiana de Cancerología

ISSN: 2346-0199,  0123-9015

Ano de publicación: 2015

Volume: 19

Número: 4

Páxinas: 239-243

Tipo: Artigo

DOI: 10.1016/J.RCCAN.2015.03.003 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Revista Colombiana de Cancerología

Resumo

Granulocytic sarcoma (GS) is an infrequent lesion associated with myelodysplastic or myeloproliferative disorders or leukemia, although it may be the first finding in an otherwise healthy patient. A case of GS is described that presented as spinal cord compression, in a patient with no underlying hematological disorder. Imaging studies disclosed a single lytic lesion in L1, which required emergency surgery. Immunohistochemical staining of the surgical biopsy sample was needed for diagnosis. Bone marrow aspirate was unremarkable. The patient received chemo-radiotherapy, dying 20 months after diagnosis of Pseudomonas aeruginosa sepsis during treatment of acute myelogenous leukemia. In short, primary GS is an infrequent and difficult to diagnose tumor. A high degree of suspicion, along with extensive immunohistochemical studies are necessary for diagnosis. Treatment should be prompt, aggressive and individualized, since the prognosis is very poor.

Referencias bibliográficas

  • Burns, A. (1823). Observations on the surgical anatomy of the head and neck. 1. F. Lucas, Jr., E. J. Coale, and Cushing & Jewett; Philadelphia: H. Carey & I. Lea. Baltimore.
  • King, A. (1853). A case of chloroma. Mon J Med Soc. 17. 97-104
  • Ripp, DJ,Davis, JW,Rengachary, SS,Lotuaco, LG,Watanabe, IS. (1989). Granulocytic sarcoma presenting as an epidural mass with cord compression. Neurosurgery. 24. 125
  • Neiman, RS,Barcos, M,Berard, C,Bonner, H,Mann, R,Rydell, RE. (1981). Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer. 48. 1426
  • Pileri, SA,Ascani, S,Cox, MC,Campidelli, C,Bacci, F,Piccioli, M. (2007). Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 21. 340
  • Yamauchi, K,Yasuda, M. (2002). Comparison in treatments of nonleukemic granulocytic sarcoma. Cancer. 94. 1739
  • O'Brien, T,Mortimer, E,DeGroot, H. (2000). Shoulder pain in an 8-year-old girl. Clin Orthop Relat Res. 372. 314-8320
  • Meltzer, JA,Jubinsky, PT. (2005). Acute myeloid leukemia presenting as spinal cord compression. Pediatr Emerg Care. 21. 670
  • Meis, JM,Butler, JJ,Osborne, BM,Manning, JT. (1986). Granulocytic sarcoma in nonleukemic patients. Cancer. 58. 2697
  • Antic, D,Elezovic, I,Milic, N,Suvajdzic, N,Vidovic, A,Perunicic, M. (2013). Is there a "gold" standard treatment for patients with isolated myeloid sarcoma?. Biomed Pharmacother. 67. 72
  • Campo, E,Swerdlow, SH,Harris, NL,Pileri, S,Stein, H,Jaffe, ES. (2011). The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 117. 5019
  • Breccia, M,Mandelli, F,Petti, MC,D'Andrea, M,Pescarmona, E,Pileri, SA. (2004). Clinicopathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution. Leuk Res. 28. 1165
  • Campidelli, C,Agostinelli, C,Stitson, R,Pileri, SA. (2009). Myeloid sarcoma: extramedullary manifestation of myeloid disorders. Am J Clin Pathol. 132. 426
  • Tsimberidou, AM,Kantarjian, HM,Estey, E,Cortes, JE,Verstovsek, S,Faderl, S. (2003). Outcome in patients with nonleukemic granulocytic sarcoma treated with chemotherapy with or without radiotherapy. Leukemia. 17. 1100
  • Bakst, RL,Tallman, MS,Douer, D,Yahalom, J. (2011). How I treat extramedullary acute myeloid leukemia. Blood. 118. 3785
  • Chevallier, P,Labopin, M,Cornelissen, J,Socié, G,Rocha, V,Mohty, M. (2011). Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation. Haematologica. 96. 1391
  • Kalayci, M,Sümer, M,Yenidünya, S,Ozdolap, S,Açikgöz, B. (2005). Spinal granulocytic sarcoma (chloroma) presenting as acute cord compression in a nonleukemic patient. Neurol India. 53. 221
  • Hutchinson, RE,Kurec, AS,Davey, FR. (1990). Granulocytic sarcoma. Clin Lab Med. 10. 889-901
Fonte de datos: Dialnet