Mutations in ribosomal protein L16 and in 23S rRNA gene in Enterococcus strains for which evernimicin MICs differ

  1. Zarazaga, M. 1
  2. Tenorio, C. 1
  3. Del Campo, R. 1
  4. Ruiz-Larrea, F. 1
  5. Torres, C. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

Journal:
Antimicrobial Agents and Chemotherapy

ISSN: 0066-4804

Year of publication: 2002

Volume: 46

Issue: 11

Pages: 3657-3659

Type: Article

DOI: 10.1128/AAC.46.11.3657-3659.2002 PMID: 12384386 SCOPUS: 2-s2.0-0036838794 WoS: WOS:000178712800054 GOOGLE SCHOLAR

More publications in: Antimicrobial Agents and Chemotherapy

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Abstract

Mutations in ribosomal protein L16 and in 23S rRNA were investigated in 22 Enterococcus strains of different species and for which the MICs of evernimicin differ (MICs, 0.023 to 16 μg/ml). Amino acid changes (Arg56His, Ile52Thr, or Arg51His) in protein L16 were found in seven strains, and a nucleotide G2535A mutation in 23S rRNA was found in 1 strain among 13 for which the MICs are ≥1 μg/ml.