Are detox diets an effective strategy for obesity and oxidation management in the short term?

  1. Ismael San Mauro Martín
  2. Victor Paredes Barato
  3. Sara Sanz Rojo
  4. Sara López Oliva
  5. Elena Garicano Vilar
  6. Paulina Gudalewska
  7. María A. Martín Cuesta
  8. Xin Rui
  9. María José Ciudad Cabañas
  10. L. Collado Yurrita
Journal of Negative and No Positive Results: JONNPR

ISSN: 2529-850X

Year of publication: 2017

Volume: 2

Issue: 9

Pages: 399-409

Type: Article

DOI: 10.19230/JONNPR.1585 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Journal of Negative and No Positive Results: JONNPR


Introduction: Detox diets are popular dieting strategies that claim to facilitate toxin elimination and weight loss, thereby promoting health and well-being.Objective: To examine whether detox diets affect antioxidant markers in blood and body composition. Methods: 14 participants were randomly divided into two groups: a) Group 1/Detox diet: followed an exclusive detox diet based on juices for three days, followed by a hypocaloric diet for 4 days; and b) Group 2/Mediterranean diet: followed a hypocaloric Mediterranean diet for 7 days.Results: there were statistically significant differences, in both groups, between the basal and final data in all study variables, except for test PAT. Weight, BMI, total fat, muscle and dROM decreased, while body water increased slightly. Weight loss and body fat were higher in group 2 (Mediterranean diet) than in group 1 (detox diet). The percentage of body water and the level of reactive oxygen metabolites increased. There was greater loss of musculature and water. In group 1, a decrease in the level of reactive oxygen metabolites was observed. However, there was a lower decrease in the body's antioxidant response, in group 1 than in group 2.Conclusion: There are reports which support that detox diets are useful for health promotion and weight loss; however, some preliminary studies suggest that certain nutritional components possess detoxification properties; we did not meet such a conclusion in our study. 

Bibliographic References

  • Allen J, Montalto M, Lovejoy J, Weber W. Detoxification in Naturopathic Medicine: A Survey. J Altern Complement Med. 2011;17(12):1175–80.
  • Altshul S. Your Simple 3-Day Diet Detox: Consider eating lighter for 24 more days [Internet]. 2014 [cited 2017 Jun 19]. Available from: day-diet-detox
  • Anderson R. Caloric Restriction and Aging: Studies in Mice and Monkeys. Toxicol Pathol. 2009;37(1):47–51.
  • Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5(1):9–19.
  • Bland J, Barrager E, Reedy R, Bland K. A Medical Food-Supplemented Detoxification Program in the Management of Chronic Health Problems. Vol. 1, Alternative therapies in health and medicine. 1995. p. 62–71.
  • Booth M. Assessment of Physical Activity: An International Perspective. Res Q Exerc Sport. 2000;71(sup2):114–20.
  • Carrotte ER, Vella AM, Lim MSC. Predictors of “Linking” Three Types of Health and Fitness-Related Content on Social Media: A Cross-Sectional Study. J Med Internet Res. 2015;17(8):e205.
  • Cline JC. Nutritional aspects of detoxification in clinical practice. Altern Ther Health Med. 2015;21(3):54–62.
  • Corleone J. The Best 2- or 3-Day Detox to Lose Weight [Internet]. 2015 [cited 2017 Jun 19]. Available from: lose-weight/
  • Dapcich V, Salvador G, Ribas L, Pérez C, Aranceta J, Serra L. Guía de la alimentación saludable. Senc. 2004;1–105.
  • Davis J, Juarez D, Hodges K. Relationship of ethnicity and body mass index with the development of hypertension and hyperlipidemia. Ethn Dis. 2013;23(1):65–70.
  • Dieta Detox en 3 días [Internet]. [cited 2017 Jun 19]. Available from:
  • Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114(12):1752–61.
  • Gómez-Ambrosi J, Silva C, Galofré JC, Escalada J, Santos S, Millán D, et al. Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int J Obes. 2012;36(2):286–94.
  • Heilbronn LK, Ravussin E. Calorie restriction and aging : review of the literature and implications for studies in humans 1 – 3. Am J Clin Nutr. 2003;78(3):361–9.
  • Huang C-J, McAllister MJ, Slusher AL, Webb HE, Mock JT, Acevedo EO. Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation. Sport Med - Open. 2015;1(1):32.
  • Hungry for Change. 3 Day Detox Plan (Friday - Sunday) [Internet]. [cited 2017 Jun 19]. Available from:
  • Instituto Nacional de Estadistica. Cuestionario de Adultos Personas de 16 y más años Estado de salud y accidentalidad Estado de Salud ( últimos 12 meses ). 1989;1–20.
  • Jackness C, Karmally W, Febres G, Conwell IM, Ahmed L, Bessler M, et al. Very low-calorie diet mimics the early beneficial effect of Roux-en-Y gastric bypass on insulin sensitivity and beta-cell Function in type 2 diabetic patients. Diabetes. 2013;62(9):3027–32.
  • Janssen I, Fortier A, Hudson R, Ross R. Effects of an energy- restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. Diabetes Care. 2002;25(3):431–8.
  • Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH. Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women. Nutr Res. 2015;35(5):409–20.
  • Klein A V., Kiat H. Detox diets for toxin elimination and weight management: A critical review of the evidence. J Hum Nutr Diet. 2015;28(6):675–86.
  • Laaksonen DE, Kainulainen S, Rissanen A, Niskanen L. Relationships between changes in abdominal fat distribution and insulin sensitivity during a very low calorie diet in abdominally obese men and women. Nutr Metab Cardiovasc Dis. 2003;13(6):349–56.
  • Lara-Castro C, Newcomer BR, Rowell J, Wallace P, Shaughnessy SM, Munoz AJ, et al. Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects. Metabolism. 2008;57(1):1–8.
  • Le Lay S, Simard G, Martinez MC, Andriantsitohaina R. Oxidative stress and metabolic pathologies: From an adipocentric point of view. Oxid Med Cell Longev. 2014;2014:908539.
  • Lobo V, Patil A, Phatak A, Chandra N, Vijaya M, Lobo C. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010;4(8):118–26.
  • MacIntosh A, Ball K. The effects of a short program of detoxification in disease-free individuals. Altern Ther Health Med. 2000;6(4):70–6.
  • Manna P, Jain SK. Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord. 2015;13(10):423–44.
  • Marseglia L, Manti S, D’Angelo G, Nicotera A, Parisi E, Di Rosa G, et al. Oxidative stress in obesity: A critical component in human diseases. Int J Mol Sci. 2015;16(1):378–400.
  • Matsuda M, Shimomura I. Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obes Res Clin Pract. 2013;7(5).
  • Mazurak N, Günther A, Grau FS, Muth ER, Pustovoyt M, Bischoff SC, et al. Effects of a 48-h fast on heart rate variability and cortisol levels in healthy female subjects. Eur J Clin Nutr. 2013;67(4):401–6.
  • NewsMail. Dietitians reveal the three worst diets for your health [Internet]. 2014 [cited 2017 Jun 19]. Available from: health/2132566/
  • Pankevich DE, Teegarden SL, Hedin AD, Jensen CL, Bale TL. Caloric Restriction Experience Reprograms Stress and Orexigenic Pathways and Promotes Binge Eating. J Neurosci. 2010;30(48):16399–407.
  • Piper MDW, Partridge L. Dietary restriction in Drosophila: Delayed aging or experimental artefact? PLoS Genet. 2007;3(4):0461–6.
  • Poljsak B, Šuput D, Milisav I. Achieving the balance between ROS and antioxidants: When to use the synthetic antioxidants. Oxid Med Cell Longev. 2013;2013:1–11.
  • Portao J, Bescós R, Irurtia A, Cacciatori E, Vallejo L. Valoración de la grasa corporal en jóvenes físicamente activos: Antropometría vs bioimpedancia. Nutr Hosp. 2009;24(5):529–34.
  • Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, et al. Oxidative stress, prooxidants, and antioxidants: The interplay. Biomed Res Int. 2014;2014:761264.
  • Rahman T, Hosen I, Islam MMT, Shekhar HU. Oxidative stress and human health. Adv Biosci Biotechnol. 2012;3(7):997–1019.
  • Savini I, Catani MV, Evangelista D, Gasperi V, Avigliano L. Obesity- associated oxidative stress: Strategies finalized to improve redox state. Int J Mol Sci. 2013;14(5):10497–538.
  • Skrha J, Kunesová M, Hilgertová J, Weiserová H, Krízová J, Kotrlíková E. Short-term very low calorie diet reduces oxidative stress in obese type 2 diabetic patients. Physiol Res. 2005;54(1):33–9.
  • Teeuwisse WM, Widya RL, Paulides M, Lamb HJ, Smit JWA, De Roos A, et al. Short-term caloric restriction normalizes hypothalamic neuronal responsiveness to glucose ingestion in patients with type 2 diabetes. Diabetes. 2012;61(12):3255–9.
  • Tomiyama AJ, Mann T, Vinas D, Hunger JM, DeJager J, Taylor SE. Low Calorie Dieting Increases Cortisol. Psychosom Med. 2010;72(4):357–64.
  • Vilagut G, Ferrer M, Rajmil L, Rebollo P, Permanyer-Miralda G, Quintana JM, et al. El Cuestionario de Salud SF-36 español: una década de experiencia y nuevos desarrollos. Gac Sanit. 2005;19(2):135–50.
  • W orld HealthOrganization. BMI classification [Internet]. [cited 2017 Jun 14]. Available from: introPage=intro_3.html