Bisfenol (A) una toxina a tener en cuenta en el enfermo renal en hemodiálisis

  1. Bosch Panadero, Enrique
  2. Mas Fontao, Sebastian 1
  3. Ruiz Priego, Alberto 2
  4. Egido, Jesús 2
  5. González Parra, Emilio 3
  1. 1 Centro de Investigación Biomédica en Red en Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Madrid, España
  2. 2 Departamento de Nefrología e Hipertensión, Madrid, España, Red Española de Investigación Renal, Madrid, España
  3. 3 Facultad de Medicina, Universidad Autónoma de Madrid, España; Fundación Renal Íñigo Álvarez de Toledo, Instituto Reina Sofía de Investigación en Nefrología, Madrid, España
Erakutsi afiliazioak +
Aldizkaria:
Revista Colombiana de Nefrología

ISSN: 2500-5006,  2389-7708

Argitalpen urtea: 2017

Zenbakien izenburua: January - June 2017

Alea: 4

Zenbakia: 1

Orrialdeak: 57-68

Mota: Artikulua

DOI: 10.22265/ACNEF.4.1.256 DIALNET GOOGLE SCHOLAR lock_openSarbide irekia editor

Beste argitalpen batzuk: Revista Colombiana de Nefrología

Garapen Iraunkorreko Helburuak

Laburpena

Introduction: Most uremic toxins are by-products of protein metabolism by action of intestinal flora. The metabolism of aromatic amino acids originates phenolic type residues. The most studied is p-cresol that is associated with renal function and vascular damage. Bisphenol A (BPA) is an exogenous molecule with characteristics similar to these aromatic uremic toxins. BPA is an estrogenic endocrine disruptor, found in tin cans, plastic bottles, epoxy resins and in some dialyzers. This molecule accumulates in patients who have impaired renal function. Observational studies have shown that exposure of BPA is linked to renal and cardiovascular injury, among many others in humans, and in animal studies a causal link has been described. Kidneys with normal renal function rapidly excrete BPA, but insufficient excretion in patients with CKD results in accumulation of BPA in the body.

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