Acerca de la enfermedad celiaca. Breve historia de la celiaquía

  1. Rodríguez Montealegre, Ángeles 1
  2. Celada, Paloma 1
  3. Bastida, Sara 1
  4. Sánchez-Muniz, Francisco J 1
  1. 1 Departamento de Nutrición y Ciencia de los Alimentos. Facultad de Farmacia. Universidad Complutense de Madrid. Madrid.
Journal of Negative and No Positive Results: JONNPR

ISSN: 2529-850X

Year of publication: 2018

Volume: 3

Issue: 12

Pages: 980-997

Type: Article

DOI: 10.19230/JONNPR.2813 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Journal of Negative and No Positive Results: JONNPR

Institutional repository: lock_openOpen access Editor


In this work on celiac disease, the authors focus mainly on the most relevant historical aspects that have been patterning knowledge on celiac disease. Once more details of the disease through their  symptoms have been known, a more rigorous profile of this pathology was made. Thus, the Celiac Diseases first was considered a chronic indigestion without relation to the type of food ingested, then it was found  that it was based on an intolerance to gliadin and other similar proteins, later that it is an autoimmune  disease. The important contributions of Areteo, Soriano, Gee, Herter, Dicke, Anderson, Marsh are reviewed  and their contributions and research have helped indisputably the knowledge of the central aspects of the  Celiac Disease. This paper does not want to obviate the work of Spanish physicians and researcher as  Santiago Cavengt, Ángel Ballabriga, Manuel Suárez Perdiguero, Isabel Polanco nor the work of the  international and national Celiacs societies and the Spanish “Ministry of Salud y Consumo”. 

Bibliographic References

  • Leffler DA, Green PH, Fasano A. Extraintestinal manifestations of coeliac disease. Nat Rev Gastroenterol Hepatol. 2015; 12(10): 561-567.
  • Lundin KE, Wijmenga C. Coeliac disease and autoimmune disease- genetic overlap and screening. Nat Rev Gastroenterol Hepatol. 2015; 12(9): 507-515.
  • Polanco, I; Larrauri, J. Does transient gluten intolerance exist? En: Kumar PJ, Walker-Simyh JA. (Eds). Coeliac disease: one hundred years. Middlesex. Leeds University Press. 1990; pp. 226-230.
  • Troncone, R; Auricchio,S. Coeliac disease. En: Wyllie R, Hyamans SS. (Eds.). Pediatric gastrointestinal disease. Filadelfia. Decker 1993; pp. 544-561.
  • Tovoli F, Masi C, Guidetti E, Negrini G, Paterini P, Bolondi L. Clinical and diagnostic aspects of gluten related disorders. World J Clin Cases. 2015; 3(3): 275-284.
  • Penagini F, Dilillo D, Meneghin F, Mameli C, Fabiano V, Zuccotti GV. Gluten-free diet in children: an approach to a nutritionally adequate and balanced diet. Nutrients 2013; 5(11): 4553-4565.
  • Kupper C. Dietary guidelines and implementation for celiac disease. Gastroenterol. 2005; 128(4 Suppl 1): S121-S127.
  • Rodrigo L, Garrote JA, Vivas S. Enfermedad Celíaca». Med Clin (Barc). 2008; 131(7): 264-270.
  • Polanco Allué I. (2008). Diagnóstico precoz de la enfermedad celíaca. Ministerio de Sanidad y Consumo (Ed.) Madrid, España.
  • Ciccocioppo R, Kruzliak P, Cangemi GC, Pohanka M, Betti E, Lauret E, Rodrigo L. The Spectrum of Differences between Childhood and Adulthood Celiac Disease. Nutrients 2015; 7(10): 8733-8751.
  • Molberg O, Mcadam SN, Körner R, Quarsten H, Kristiansen C, Madsen L, Fugger L, Scott H, Norén O, Roepstorff P, Lundin KE, Sjöström H, Sollid LM. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gutderived T cells in celiac disease. Nat Med. 1998; 4(6):713-717.
  • Tommasini A, Not T, Ventura A. Ages of celiac disease: from changing environment to improved diagnostics. World J Gastroenterol. 2011; 17(32): 3665-3671
  • Nadhem ON, Azeez G, Smalligan RD, Urban S. Review and practice guidelines for celiac disease in 2014. Postgrad Med. 2015; 127(3): 259- 265.
  • Woodward J. Improving outcomes of refractory celiac disease - current and emerging treatment strategies. Clin Experimen Gastroenterol. 2016; 9: 225-236.
  • Fasano A, Catáis C, Current approaches to diagnosis and treatment of celiac disease an evolving spectrum. Gastroenterology 2001; 120: 636- 651.
  • Fasano A. Should we screen for coeliac disease? Yes. BMJ. 2009; 339: b3592.
  • García Almeida JM, García Alemán J, Martínez Alfaro B, Vilchez López FJ, Maraver Selfa S. Enfermedad celiaca, dieta controlada en gluten. En: de Luis Román D A, Bellido Guerrero D, García Luna PP. (Eds.). Dietoterapia, Nutrición Clínica y Metabolismo. Ed: Díaz de Santos. Madrid. 2012; pp. 247-249.
  • García Nieto VM. Historia de la enfermedad celíaca. En: Rodrigo L, Peña AS. (Eds.). Enfermedad celíaca y sensibilidad al gluten no celíaca. OmniaScience. Barcelona, España: 2013; pp. 45-59.
  • Vogten AJ, Peña AS. Coeliac disease: one century after Samuel Gee (1888). Neth J Med. 1987; 31(5-6): 253-255.
  • Losowsky MS. A history of coeliac disease. Dig Dis. 2008. 26(2); 112- 120.
  • ayer/920266.html
  • Cavengt S. Infantilismo o patocativismo. En: Endocrinología infantil. Ruiz Hermanos eds. Madrid. 1922; pp. 131-170.
  • Cavengt S. Consideraciones clínicas sobre la celiaquia. Acta Ped Esp. 1950; 8: 199.
  • Suárez Perdiguero M. Enfermedad celíaca y síndrome celíaco. Concepto y patogénesis. Rev Esp Pediatr. 1945; 1: 683-695.
  • Dicke Wk, Weijers HA, Van De Kamer JH. Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatr. 1953; 42(1): 34-42.
  • Shiner M. Duodenal biopsy. Lancet 1956; 1: 17–19.
  • Abel EK. The rise and fall of celiac disease in the United States. J Hist Med Allied Sci. 2010; 65(1): 81-105.
  • golpes-de-estado/
  • Ballabriga Aguado A. Tratamiento de la enfermedad celíaca con especial consideración a sus aspectos dietéticos. Acta Ped Esp. 1949; 7: 1519-1541.
  • Anderson CM, French JM, Sammons HG, Frazer AC, Gerrard JW, Smellie JM. Coeliac disease; gastrointestinal studies and the effect of dietary wheat flour. Lancet 1952; 1(17): 836-842.
  • Paulley JW Observation on the aetology of idiopathic steatorrhoea; jejunal and lymphnode biopsies. Br Med J. 1954; 2(4900): 1318-1321.
  • Márquez Infante M. Historia de la enfermedad celiaca. En: Asociación de Celíacos de Madrid. Consejería de Sanidad y Consumo. Todo sobre la enfermedad celiaca. 2008
  • Catassi C, Bearzi I, Holmes GK. Association of celiac disease and intestinal lymphomas and other cancers. Gastroenterology 2005; 128(4 Suppl 1): S79-S86.
  • Ellis J: Coeliac disease and other gluten-sensitive disorders. En: Buttriss J (ed): Adverse Reactions to Food. Blackwell Science, London. 2002; pp 112–130.
  • Falchuk ZM, Rogentine GN, Strober W: Predominance of histocompatibility antigen HLA8 in patients with gluten-sensitive enteropathy. J Clin Invest. 1972; 51: 1602–1605.
  • Stokes PL, Asquith P, Holmes GK, Mackintosh P, Cooke WT. Histocompatibility antigens associated with adult coeliac disease. Lancet 1972; 2: 162–164.
  • Granditsch G, Ludwig H, Polymenidis Z, Wick G. Letter: Coeliac disease and HL-A8. Lancet 1973; 2(7834): 908-909.
  • Berger E: Allergic pathogenesis of celiac disease with studies of the splitting up of pathogenic antigens by enzymes. Bibl Paediatr. 1958; 67: 1–55.
  • Chorzelski TP, Sulej J, Tchorzewska H, Jablonska S, Beutner EH, Kumar V. IgA class endomysium antibodies in dermatitis herpetiformis and celiac disease. Ann NY Acad Sci. 1983; 420: 325–334.
  • Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997; 3: 797–801.
  • March MN. Gluten sensitivity and latency: can patterns of intestinal antibody secretion define the great 'silent majority?'. Gastroenterology. 1993; 104(5):1550-
  • Ministerio de Sanidad y Política Social. Nuevo protocolo de detección precoz de la celiaquía. Boletín impacto. DG Agencia de Calidad del SNS. Marzo 2018.
  • Molina-Infante J, Santolaria S, Sanders DS, Fernández-Bañares F. Systematic review: noncoeliac gluten sensitivity. Aliment Pharmacol Ther. 2015; 41(9): 807-820.
  • Moreno ML, Rodríguez-Herrera A, Sousa C, Comino I. Biomarkers to monitor glutenfree diet compliance in celiac patients. Nutrients 2017; 6(9): 1.
  • Syage JA, Kelly CP, Dickason MA, Ramirez AC, Leon F, Dominguez R, Sealey-Voyksner JA. Determination of gluten consumption in celiac disease patients on a gluten-free diet. Am J Clin Nutr. 2018; 107(2): 201- 207.
  • Newnham ED. Coeliac disease in the 21st century: paradigm shifts in the modern age. J Gastroenterol Hepatol. 2017; 32(Suppl 1): 82-85.